COSMOCORE 2.6C18
Features
- 2.6 µm Core Shell Particle
- Increased loading capacity
- Excellent pH stability (1.5-10)

Product Information
About Core-Shell Particles
Column Specifications
Excellent pH Stability
Under accelerated pH 10.4, 40°C stability test, COSMOCORE C18 column shows superior stability compared with other core shell C18 phases.
Test condition | ||||
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Column size | 2.1 mm I.D. x 100 mm | Temperature | 40 °C | |
Mobile phase: | 0.35% ammonium hydroxide/ acetonitrile = 90/10 (pH 10.4) | Sample | caffeine 0.05 mg/ml | |
Flow rate | 0.4 ml/min. | Inj.Vol. | 1 µl |
Reduced Back Pressure and Faster Analyses
COSMOCORE 2.6C18 delivers performance equivalent to sub-2 µm particles at faster flow rate and analysis time while maintaining a lower back pressure. COSMOCORE can also be used in longer column size to gain additional resolution.
Condition: Column size; 2.1mm I.D. - 50 mm, Mobile phase; Acetonitrile / Water = 70 / 30, Temperature; 40°C, Sample; Amylbenzene
Higher retention and loading capacity than competitors' core-shell columns
Retention
COSMOCORE 2.6C18 features high retention and better separation compared to other core-shell columns.
Condition | ||||
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Column size | 2.1 mm I.D. x 50 mm | Sample |
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Mobile phase: | A: Acetonitrile / Water = 50 / 50 B: Acetonitrile / Water = 70 / 30 B conc. 0→100% (0-4 min), 100%(4-5 min) |
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Flow rate | 0.4 ml/min | |||
Temperature | 40 °C | |||
Detection | UV254nm | Inj.Vol. | 0.5 µl |
Low Bleed - Suitable for LC-MS
COSMOCORE 2.6C18 has low column bleed and consequently low MS noise level.
Condition | ||||
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Column size | 4.6 mm I.D. x 150 mm | |||
Mobile phase | A: 0.1% Formic Acid B: Acetonitrile B conc. 5→100% (0 - 5 min), 100% (5 -10 min), 100→5% (10 - 11 min), 5% (11 - 17 min) |
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Flow rate | 0.2 ml/min | |||
Temperature | 40°C | |||
Detection | MS (TIC (+), MW 50-1000) |
Applications
Sharp Peaks with Many Types of Compounds
COSMOCORE 2.6C18 features a special end capping treatment that effectively shields residual silanol groups, yielding sharp peaks for basic compounds and metal coordination complexes.
Basic compounds
Amitriptyline

Condition | |
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Column Size | 2.1 mm I.D. x 50 mm |
Mobile Phase | Acetonitrile / 20mmol/l Phosphoric Acid Buffer(pH7.0) = 60 / 40 |
Flow Rate | 0.4 ml/min |
Temperature | 40°C |
Detection | UV254nm |
Sample |
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Inj.Vol. | 0.5 µl |
Haloperidol

Condition | |
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Column Size | 2.1 mm I.D. x 50 mm |
Mobile Phase | A; Acetonitrile/ 20mmol/l Phosphate buffer(pH7.0) = 10/90 B; Acetonitrile/ 20mmol/l Phosphate buffer(pH7.0) = 50/50 B conc. 0→100%(0→3min), 100%(3-5min) |
Flow Rate | 0.4 ml/min |
Temperature | 40°C |
Detection | UV220nm |
Sample |
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Inj.Vol. | 0.5 µl |
Procainamide

Condition | |
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Column Size | 2.1 mm I.D. x 50 mm |
Mobile Phase | Acetonitrile/ 20mmol/l Phosphate buffer(pH7.0) = 10/90 |
Flow Rate | 0.4 ml/min |
Temperature | 40°C |
Detection | UV270nm |
Sample |
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Inj.Vol. | 0.5 µl |
Caffeine

Condition | |
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Column Size | 2.1 mm I.D. x 100 mm |
Mobile Phase | Acetonitrile/ H2O = 10/90 |
Flow Rate | 0.4 ml/min |
Temperature | 40°C |
Detection | UV275nm |
Sample |
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Inj.Vol. | 1.0 µl |
Ciprofloxacin

Condition | |
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Column Size | 2.1 mm I.D. x 100 mm |
Mobile Phase | Acetonitrile/ 20mmol/l Phosphate buffer(pH2.5) = 10/90 |
Flow Rate | 0.4 ml/min |
Temperature | 40°C |
Detection | UV278nm |
Sample |
|
Inj.Vol. | 0.5 µl |
Metal coordination complexes
Oxine-copper

Condition | |
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Column Size | 2.1 mm I.D. x 50 mm |
Mobile Phase | Acetonitrile / 20mmol/l Phosphoric Acid = 10 / 90 |
Flow Rate | 0.4 ml/min |
Temperature | 40°C |
Detection | UV254nm |
Sample |
|
Inj.Vol. | 0.5 µl |
Usage information
Column | 2.6 COSMOCORE C18 | ||
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I.D. (mm) | 2.1 | 3 | 4.6 |
Washing method | 1. Remove buffer, salts and/or acid from column: wash for 10-15 min. using the mobile phase last used, without buffer, salts or acid. For example, if your mobile phase was 50:50 methanol/20 mmol/l phosphate buffer, wash with 50:50 methanol/water. 2. (If you used a buffer, always do step 1 first!) Remove adsorbed compounds and fix unstable baselines by washing with methanol and/or THF. |
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Storage conditions | Short-term (up to a week): Remove buffer, salts and/or acid from column: wash for 10-15 min. using the mobile phase last used, without buffer, salts or acid. For example, if your mobile phase was 50:50 methanol/20 mmol/l phosphate buffer, wash with 50:50 methanol/water. Long-term: Remove buffer, salts and/or acid from column: wash for 10-15 min. using the mobile phase last used, without buffer, salts or acid. Then, replace the solvent with 70% methanol or acetonitrile : 30% water. In either case, tightly plug the column, and store in a cool and dry place. |
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Usable pH range | pH1.5~pH10 (pH 2-7.5 recommended) |
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Max. pressure | 60MPa | ||
Temperature range | The maximum usable temperature is 60°C. However. for regular use, please use at a constant temperature between 20°C and 50°C. | ||
Usable solvents | Any solvent that will not dissolve the silica gel (such as alkaline solutions) or cleave the stationary phase (such as very acidic solutions) is usable. Note: For solvents with high viscosity, please watch the system pressure and keep it below 60 MPa. Also, please wash the column after using acidic mobile phases or solvents with high freezing points. |
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Other instructions | - Buffer concentration is usually sufficient at 0.005 - 0.02 mol/L. - Always filter mobile phases using a 0.45 µm or finer filter before use. - Reproducibility may worsen when using a mobile phase that is more than 90% water. |
Downloads
Brochures
- COSMOCORE Series
(5.5 MB)
Ordering Information
Analytical Column (Particle size : 2.6 µm)
COSMOCORE 2.6C18
Product Name | Size | Product No. | Price |
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COSMOCORE 2.6C18 | |||
2.1 mm I.D. x 30 mm | 12632-31 | Inquire Now |
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2.1 mm I.D. x 50 mm | 12631-41 | ||
2.1 mm I.D. x 75 mm | 12630-51 | ||
2.1 mm I.D. x 100 mm | 12614-71 | ||
2.1 mm I.D. x 150 mm | 12612-91 | ||
3.0 mm I.D. x 30 mm | 12611-01 | ||
3.0 mm I.D. x 50 mm | 12609-51 | ||
3.0 mm I.D. x 75 mm | 12608-61 | ||
3.0 mm I.D. x 100 mm | 12607-71 | ||
3.0 mm I.D. x 150 mm | 12602-21 | ||
4.6 mm I.D. x 30 mm | 12601-31 | ||
4.6 mm I.D. x 50 mm | 12600-41 | ||
4.6 mm I.D. x 75 mm | 12599-91 | ||
4.6 mm I.D. x 100 mm | 12598-01 | ||
4.6 mm I.D. x 150 mm | 12597-11 | ||
4.6 mm I.D. x 250 mm | 12596-21 |
Other sizes may be available.
>> For UHPLC (COSMOCORE) fittings and adapters, please see this page.